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1

Metabolism, pharmacokinetics and pharmacodynamics of the factor Xa inhibitor apixaban in rabbits

Donglu Zhang, Kan He, Nirmala Raghavan, Lifei Wang, Earl J. Crain, Bing He, Baomin Xin, Joseph M. Luettgen, Pancras C. Wong

Journal:

Journal of Thrombosis and Thrombolysis

Year:

2010

Language:

english

File:

PDF, 784 KB

english, 2010

2

Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa

Yun-Long Li, John M. Fevig, Joseph Cacciola, Joseph Buriak Jr., Karen A. Rossi, Janan Jona, Robert M. Knabb, Joseph M. Luettgen, Pancras C. Wong, Stephen A. Bai, Ruth R. Wexler, Patrick Y.S. Lam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 180 KB

english, 2006

3

Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies

P. C. WONG, E. J. CRAIN, B. XIN, R. R. WEXLER, P. Y. S. LAM, D. J. PINTO, J. M. LUETTGEN, R. M. KNABB

Journal:

Journal of Thrombosis and Haemostasis

Year:

2008

Language:

english

File:

PDF, 371 KB

english, 2008

4

Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1 H -pyrazolo[3,4- c ]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Pinto, Donald J. P., Orwat, Michael J., Koch, Stephanie, Rossi, Karen A., Alexander, Richard S., Smallwood, Angela, Wong, Pancras C., Rendina, Alan R., Luettgen, Joseph M., Knabb, Robert M., He, Kan,

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 666 KB

english, 2007

5

Apixaban, an oral direct factor Xa inhibitor, inhibits human clot-bound factor Xa activity in vitro

Jiang, Xiaosui, Crain, Earl J., Luettgen, Joseph M., Schumacher, William A., Wong, Pancras C.

Journal:

Thrombosis and Haemostasis

Year:

2009

Language:

english

File:

PDF, 68 KB

english, 2009

6

Multiscale smoothing error models

Luettgen, M.R., Willsky, A.S.

Journal:

IEEE Transactions on Automatic Control

Year:

1995

Language:

english

File:

PDF, 367 KB

english, 1995

7

Synthesis and P1′ SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors

Ladziata, Vladimir (Uladzimir), Glunz, Peter W., Zou, Yan, Zhang, Xiaojun, Jiang, Wen, Jacutin-Porte, Swanee, Cheney, Daniel L., Wei, Anzhi, Luettgen, Joseph M., Harper, Timothy M., Wong, Pancras C.,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 1.82 MB

english, 2016

8

First in human study to assess safety, pharmacokinetics and pharmacodynamics of BMS-962212, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese and Japanese healthy subjects

Perera, Vidya, Luettgen, Joseph M., Wang, Zhaoqing, Frost, Charles E., Yones, Cynthia, Russo, Cesare, Lee, John, Zhao, Yue, LaCreta, Frank P., Ma, Xuewen, Knabb, Robert M., Seiffert, Dietmar, DeSouza,

Journal:

British Journal of Clinical Pharmacology

Year:

2018

Language:

english

File:

PDF, 1.01 MB

english, 2018

9

Analyzing business process anomalies using autoencoders

Nolle, Timo, Luettgen, Stefan, Seeliger, Alexander, Mühlhäuser, Max

Journal:

Machine Learning

Year:

2018

Language:

english

File:

PDF, 1.03 MB

english, 2018

10

Factor XIa Inhibitors as New Anticoagulants

Quan, Mimi L., Pinto, Donald J. P., Smallheer, Joanne M., Ewing, William R., Rossi, Karen A., Luettgen, Joseph M., Seiffert, Dietmar A., Wexler, Ruth R.

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 13.86 MB

english, 2018

11

Field testing of an onsite sanitation system on apartment building blackwater using biological treatment and electrochemical disinfection

Varigala, Siva Kumar, Hegarty-Craver, Meghan, Krishnaswamy, Srinivas, Madhavan, Prakash, Basil, Milan, Rosario, Praveen, Raj, Antony, Barani, Viswa, Cid, Clement A., Grego, Sonia, Luettgen, Michael

Journal:

Environmental Science Water Research & Technology

Year:

2020

File:

PDF, 2.32 MB

2020

12

5-Amidinoindoles as Dual Inhibitors of Coagulation Factors IXa and Xa.

Douglas G. Batt, Jennifer X. Qiao, Dilip P. Modi, Gregory C. Houghton, Deborah A. Pierson, Karen A. Rossi, Joseph M. Luettgen, Robert M. Knabb, P. K. Jadhav, Ruth R. Wexler

Journal:

Year:

2005

File:

PDF, 17 KB

2005

13

Lower Risk and Costs through Marketing Affiliates

Robert A. Luettgen

Journal:

Natural Gas & Electricity

Year:

1991

Language:

english

File:

PDF, 435 KB

english, 1991

14

Checklist For Gas Marketing Considerations

Robert A. Luettgen

Journal:

Natural Gas & Electricity

Year:

1992

Language:

english

File:

PDF, 544 KB

english, 1992

15

SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa

Joanne M. Smallheer, Richard S. Alexander, Jianmin Wang, Shuaige Wang, Suanne Nakajima, Karen A. Rossi, Angela Smallwood, Frank Barbera, Debra Burdick, Joseph M. Luettgen, Robert M. Knabb, Ruth R. Wex

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 331 KB

english, 2004

16

5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa

Douglas G. Batt, Jennifer X. Qiao, Dilip P. Modi, Gregory C. Houghton, Deborah A. Pierson, Karen A. Rossi, Joseph M. Luettgen, Robert M. Knabb, P.K. Jadhav, Ruth R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 303 KB

english, 2004

17

Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors

Mimi L. Quan, Qi Han, John M. Fevig, Patrick Y.S. Lam, Steve Bai, Robert M. Knabb, Joseph M. Luettgen, Pancras C. Wong, Ruth R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 117 KB

english, 2006

18

Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues

Jennifer X. Qiao, Xuhong Cheng, Joanne M. Smallheer, Robert A. Galemmo, Spencer Drummond, Donald J.P. Pinto, Daniel L. Cheney, Kan He, Pancras C. Wong, Joseph M. Luettgen, Robert M. Knabb, Ruth R. Wex

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 414 KB

english, 2007

19

SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa

Jennifer X. Qiao, Chong-Hwan Chang, Daniel L. Cheney, Paul E. Morin, Gren Z. Wang, Sarah R. King, Tammy C. Wang, Alan R. Rendina, Joseph M. Luettgen, Robert M. Knabb, Ruth R. Wexler, Patrick Y.S. Lam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 1.32 MB

english, 2007

20

Enantiopure five-membered cyclicdiamine derivatives as potent and selective inhibitors of factor Xa. Improving in vitro metabolic stability via core modifications

Jennifer X. Qiao, Tammy C. Wang, Gren Z. Wang, Daniel L. Cheney, Kan He, Alan R. Rendina, Baomin Xin, Joseph M. Luettgen, Robert M. Knabb, Ruth R. Wexler, Patrick Y.S. Lam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 506 KB

english, 2007

21

Design, structure–activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors

Jeffrey G. Varnes, Dean A. Wacker, Irina C. Jacobson, Mimi L. Quan, Christopher D. Ellis, Karen A. Rossi, Ming Y. He, Joseph M. Luettgen, Robert M. Knabb, Steven Bai, Kan He, Patrick Y.S. Lam, Ruth R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 188 KB

english, 2007

22

Structure–activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors

Jeffrey G. Varnes, Dean A. Wacker, Donald J.P. Pinto, Michael J. Orwat, Jay P. Theroff, Brian Wells, Robert A. Galemo, Joseph M. Luettgen, Robert M. Knabb, Steven Bai, Kan He, Patrick Y.S. Lam, Ruth R

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 164 KB

english, 2008

23

Sulfonamidolactam inhibitors of coagulation factor Xa

Joanne M. Smallheer, Shuaige Wang, Mia L. Laws, Suanne Nakajima, Zilun Hu, Wei Han, Irina Jacobson, Joseph M. Luettgen, Karen A. Rossi, Alan R. Rendina, Robert M. Knabb, Ruth R. Wexler, Patrick Y.S. L

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 273 KB

english, 2008

24

Structure–activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties

James R. Corte, Tianan Fang, Donald J.P. Pinto, Wei Han, Zilun Hu, Xiang-Jun Jiang, Yun-Long Li, Jolicia F. Gauuan, Mark Hadden, Darren Orton, Alan R. Rendina, Joseph M. Luettgen, Pancras C. Wong, Kan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 266 KB

english, 2008

25

Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: Discovery of novel, highly potent inhibitors of Factor Xa

Jennifer X. Qiao, Daniel L. Cheney, Richard S. Alexander, Angela M. Smallwood, Sarah R. King, Kan He, Alan R. Rendina, Joseph M. Luettgen, Robert M. Knabb, Ruth R. Wexler, Patrick Y.S. Lam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 802 KB

english, 2008

26

Highly efficacious factor Xa inhibitors containing α-substituted phenylcycloalkyl P4 moieties

Jennifer X. Qiao, Sarah R. King, Kan He, Pancras C. Wong, Alan R. Rendina, Joseph M. Luettgen, Baomin Xin, Robert M. Knabb, Ruth R. Wexler, Patrick Y.S. Lam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 207 KB

english, 2009

27

Phenyltriazolinones as potent factor Xa inhibitors

Mimi L. Quan, Donald J.P. Pinto, Karen A. Rossi, Steven Sheriff, Richard S. Alexander, Eugene Amparo, Kevin Kish, Robert M. Knabb, Joseph M. Luettgen, Paul Morin, Angela Smallwood, Francis J. Woerner,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.17 MB

english, 2010

28

Speciation of cyclo(Pro-Gly)3and its divalent metal-ion complexes by electrospray ionization mass spectrometry

Andrew R.S. Ross, Sarah L. Luettgen

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2005

Language:

english

File:

PDF, 436 KB

english, 2005

29

Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors

Celia Dominguez, Daniel E. Duffy, Qi Han, Richard S. Alexander, Robert A. Galemmo Jr., Jeongsook M. Park, Pancras C. Wong, Eugene C. Amparo, Robert M. Knabb, Joseph Luettgen, Ruth R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 338 KB

english, 1999

30

Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor

Kan He, Joseph M. Luettgen, Donglu Zhang, Bing He, James E. Grace, Baomin Xin, Donald J. P. Pinto, Pancras C. Wong, Robert M. Knabb, Patrick Y. S. Lam, Ruth R. Wexler, Scott J. Grossman

Journal:

European Journal of Drug Metabolism and Pharmacokinetics

Year:

2011

Language:

english

File:

PDF, 366 KB

english, 2011

31

5-Amidinobenzo[b]thiophenes as dual inhibitors of factors IXa and Xa

Jennifer X. Qiao, Xuhong Cheng, Dilip P. Modi, Karen A. Rossi, Joseph M. Luettgen, Robert M. Knabb, Prabhakar K. Jadhav, Ruth R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 311 KB

english, 2005

32

Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa

John M. Fevig, Joseph Cacciola, Joseph Buriak Jr., Karen A. Rossi, Robert M. Knabb, Joseph M. Luettgen, Pancras C. Wong, Stephen A. Bai, Ruth R. Wexler, Patrick Y.S. Lam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 166 KB

english, 2006

33

Nonbenzamidine tetrazole derivatives as factor Xa inhibitors

Mimi L Quan, Christopher D Ellis, Ming Y He, Ann Y Liauw, Francis J Woerner, Richard S Alexander, Robert M Knabb, Patrick Y.S Lam, Joseph M Luettgen, Pancras C Wong, Matthew R Wright, Ruth R Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 218 KB

english, 2003

34

Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors

Mimi L. Quan, Christopher D. Ellis, Ming Y. He, Ann Y. Liauw, Patrick Y.S. Lam, Karen A. Rossi, Robert M. Knabb, Joseph M. Luettgen, Matthew R. Wright, Pancras C. Wong, Ruth R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 260 KB

english, 2003

35

Discovery of 3-Amino-4-Chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library

Patrick Y.S. Lam, Jessica J. Adams, Charles G. Clark, W.Jason Calhoun, Joseph M. Luettgen, Robert M. Knabb, Ruth R. Wexler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 216 KB

english, 2003

36

Preventing Violent Re-offending in Not Criminally Responsible Patients: An Evaluation of a Continuity of Treatment Program

James Luettgen, Wendy E Chrapko, John R Reddon

Journal:

International Journal of Law and Psychiatry

Year:

1998

Language:

english

File:

PDF, 58 KB

english, 1998

37

Non-line-of-sight single-scatter propagation model

Luettgen, Mark R., Shapiro, Jeffrey H., Reilly, David M.

Journal:

Journal of the Optical Society of America A

Year:

1991

Language:

english

File:

PDF, 963 KB

english, 1991

38

BMS-593214, an active site-directed factor VIIa inhibitor: Enzyme kinetics, antithrombotic and antihaemostatic studies

Wong, P. C., Luettgen, J. M., Rendina, A. R., Kettner, C. A., Xin, B., Knabb, R. M., Wexler, R., Priestley, E. S.

Journal:

Thrombosis and Haemostasis

Year:

2010

Language:

english

File:

PDF, 407 KB

english, 2010

39

Multiscale representations of Markov random fields

Luettgen, M.R., Karl, W.C., Willsky, A.S., Tenney, R.R.

Journal:

IEEE Transactions on Signal Processing

Year:

1993

Language:

english

File:

PDF, 2.03 MB

english, 1993

40

Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF–FVIIa inhibitors

Zhang, Xiaojun, Glunz, Peter W., Jiang, Wen, Schmitt, Aaron, Newman, Makenzie, Barbera, Frank A., Bozarth, Jeffery M., Rendina, Alan R., Wei, Anzhi, Wen, Xiao, Rossi, Karen A., Luettgen, Joseph M., Wo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.03 MB

english, 2013

41

Direct probe electrospray (and nanospray) ionization mass spectrometry of neat ionic liquids

Dyson, Paul J., Khalaila, Isam, Luettgen, Sarah, McIndoe, J. Scott, Zhao, Dongbin

Journal:

Chemical Communications

Year:

2004

Language:

english

File:

PDF, 309 KB

english, 2004

42

Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor

Priestley, E. Scott, De Lucca, Indawati, Zhou, Jinglan, Zhou, Jiacheng, Saiah, Eddine, Stanton, Robert, Robinson, Leslie, Luettgen, Joseph M., Wei, Anzhi, Wen, Xiao, Knabb, Robert M., Wong, Pancras C.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 542 KB

english, 2013

43

Nonbenzamidine acylsulfonamide tissue factor–factor VIIa inhibitors

Glunz, Peter W., Zhang, Xiaojun, Zou, Yan, Delucca, Indawati, Nirschl, Alexandra H., Cheng, Xuhong, Weigelt, Carolyn A., Cheney, Daniel L., Wei, Anzhi, Anumula, Rushith, Luettgen, Joseph M., Rendina,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.60 MB

english, 2013

44

Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors

Zhang, Xiaojun, Jiang, Wen, Jacutin-Porte, Swanee, Glunz, Peter W., Zou, Yan, Cheng, Xuhong, Nirschl, Alexandra H., Wurtz, Nicholas R., Luettgen, Joseph M., Rendina, Alan R., Luo, Gang, Harper, Timoth

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.18 MB

english, 2014

45

Apixaban inhibition of factor Xa: Microscopic rate constants and inhibition mechanism in purified protein systems and in human plasma

Luettgen, Joseph M., Knabb, Robert M., He, Kan, Pinto, Donald J. P., Rendina, Alan R.

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1005 KB

english, 2011

46

Tetrahydroquinoline Derivatives as Potent and Selective Factor XIa Inhibitors

Quan, Mimi L., Wong, Pancras C., Wang, Cailan, Woerner, Francis, Smallheer, Joanne M., Barbera, Frank A., Bozarth, Jeffrey M., Brown, Randi L., Harpel, Mark R., Luettgen, Joseph M., Morin, Paul E., Pe

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.17 MB

english, 2014

47

Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties

Orwat, Michael J., Qiao, Jennifer X., He, Kan, Rendina, Alan R., Luettgen, Joseph M., Rossi, Karen A., Xin, Baomin, Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y.S., Pinto, Donald J.P.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 400 KB

english, 2014

48

Removal of Carbon from Hot Caustic Solution.

Luettgen, A. J., Whisler, K. S., Bauman, H. D.

Journal:

Industrial & Engineering Chemistry

Year:

1946

Language:

english

File:

PDF, 350 KB

english, 1946

49

[IEEE Proceedings of ICASSP '93 - Minneapolis, MN, USA (1993.04.27-1993.04.30)] IEEE International Conference on Acoustics Speech and Signal Processing - Multiscale representations of Markov random fields

Luettgen, M.R., Karl, W.C., Willsky, A.S., Tenney, R.R.

Year:

1993

Language:

english

File:

PDF, 409 KB

english, 1993

50

Efficient multiscale regularization with applications to the computation of optical flow

Luettgen, M.R., Clem Karl, W., Willsky, A.S.

Journal:

IEEE Transactions on Image Processing

Year:

1994

Language:

english

File:

PDF, 1.94 MB

english, 1994

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